Latest news with #multiple sclerosis
Arab News
2 days ago
- Health
- Arab News
Harvard scientists say research could be set back years after funding freeze
CAMBRIDGE: Harvard University professor Alberto Ascherio's research is literally frozen. Collected from millions of US soldiers over two decades using millions of dollars from taxpayers, the epidemiology and nutrition scientist has blood samples stored in liquid nitrogen freezers within the university's T.H. Chan School of Public Health. The samples are key to his award-winning research, which seeks a cure to multiple sclerosis and other neurodegenerative diseases. But for months, Ascherio has been unable to work with the samples because he lost $7 million in federal research funding, a casualty of Harvard's fight with the Trump administration. 'It's like we have been creating a state-of-the-art telescope to explore the universe, and now we don't have money to launch it,' said Ascherio. 'We built everything and now we are ready to use it to make a new discovery that could impact millions of people in the world and then, 'Poof. You're being cut off.'' Researchers laid off and science shelved The loss of an estimated $2.6 billion in federal funding at Harvard has meant that some of the world's most prominent researchers are laying off young researchers. They are shelving years or even decades of research, into everything from opioid addiction to cancer. And despite Harvard's lawsuits against the administration, and settlement talks between the warring parties, researchers are confronting the fact that some of their work may never resume. The funding cuts are part of a monthslong battle that the Trump administration has waged against some the country's top universities including Columbia, Brown and Northwestern. The administration has taken a particularly aggressive stance against Harvard, freezing funding after the country's oldest university rejected a series of government demands issued by a federal antisemitism task force. The government had demanded sweeping changes at Harvard related to campus protests, academics and admissions — meant to address government accusations that the university had become a hotbed of liberalism and tolerated anti-Jewish harassment. Research jeopardized, even if court case prevails Harvard responded by filing a federal lawsuit, accusing the Trump administration of waging a retaliation campaign against the university. In the lawsuit, it laid out reforms it had taken to address antisemitism but also vowed not to 'surrender its independence or relinquish its constitutional rights.' 'Make no mistake: Harvard rejects antisemitism and discrimination in all of its forms and is actively making structural reforms to eradicate antisemitism on campus,' the university said in its legal complaint. 'But rather than engage with Harvard regarding those ongoing efforts, the Government announced a sweeping freeze of funding for medical, scientific, technological, and other research that has nothing at all to do with antisemitism.' The Trump administration denies the cuts were made in retaliation, saying the grants were under review even before the demands were sent in April. It argues the government has wide discretion to cancel federal contracts for policy reasons. The funding cuts have left Harvard's research community in a state of shock, feeling as if they are being unfairly targeted in a fight has nothing to do with them. Some have been forced to shutter labs or scramble to find nongovernment funding to replace lost money. In May, Harvard announced that it would put up at least $250 million of its own money to continue research efforts, but university President Alan Garber warned of 'difficult decisions and sacrifices' ahead. Ascherio said the university was able to pull together funding to pay his researchers' salaries until next June. But he's still been left without resources needed to fund critical research tasks, like lab work. Even a year's delay can put his research back five years, he said. Knowledge lost in funding freeze 'It's really devastating,' agreed Rita Hamad, the director of the Social Policies for Health Equity Research Center at Harvard, who had three multiyear grants totaling $10 million canceled by the Trump administration. The grants funded research into the impact of school segregation on heart health, how pandemic-era policies in over 250 counties affected mental health, and the role of neighborhood factors in dementia. At the School of Public Health, where Hamad is based, 190 grants have been terminated, affecting roughly 130 scientists. 'Just thinking about all the knowledge that's not going to be gained or that is going to be actively lost,' Hamad said. She expects significant layoffs on her team if the funding freeze continues for a few more months. 'It's all just a mixture of frustration and anger and sadness all the time, every day.' John Quackenbush, a professor of computational biology and bioinformatics at the School of Public Health, has spent the past few months enduring cuts on multiple fronts. In April, a multimillion dollar grant was not renewed, jeopardizing a study into the role sex plays in disease. In May, he lost about $1.2 million in federal funding for in the coming year due to the Harvard freeze. Four departmental grants worth $24 million that funded training of doctoral students also were canceled as part of the fight with the Trump administration, Quackenbush said. 'I'm in a position where I have to really think about, 'Can I revive this research?'' he said. 'Can I restart these programs even if Harvard and the Trump administration reached some kind of settlement? If they do reach a settlement, how quickly can the funding be turned back on? Can it be turned back on?' The researchers all agreed that the funding cuts have little or nothing to do with the university's fight against antisemitism. Some, however, argue changes at Harvard were long overdue and pressure from the Trump administration was necessary. Bertha Madras, a Harvard psychobiologist who lost funding to create a free, parent-focused training to prevent teen opioid overdose and drug use, said she's happy to see the culling of what she called 'politically motivated social science studies.' White House pressure a good thing? Madras said pressure from the White House has catalyzed much-needed reform at the university, where several programs of study have 'really gone off the wall in terms of being shaped by orthodoxy that is not representative of the country as a whole.' But Madras, who served on the President's Commission on Opioids during Trump's first term, said holding scientists' research funding hostage as a bargaining chip doesn't make sense. 'I don't know if reform would have happened without the president of the United States pointing the bony finger at Harvard,' she said. 'But sacrificing science is problematic, and it's very worrisome because it is one of the major pillars of strength of the country.' Quackenbush and other Harvard researchers argue the cuts are part of a larger attack on science by the Trump administration that puts the country's reputation as the global research leader at risk. Support for students and post-doctoral fellows has been slashed, visas for foreign scholars threatened, and new guidelines and funding cuts at the NIH will make it much more difficult to get federal funding in the future, they said. It also will be difficult to replace federal funding with money from the private sector. 'We're all sort of moving toward this future in which this 80-year partnership between the government and the universities is going to be jeopardized,' Quackenbush said. 'We're going to face real challenges in continuing to lead the world in scientific excellence.'
The Independent
3 days ago
- Health
- The Independent
Harvard scientists say research could be set back years after funding freeze
Harvard University professor Alberto Ascherio's research is literally frozen. Collected from millions of U.S. soldiers over two decades using millions of dollars from taxpayers, the epidemiology and nutrition scientist has blood samples stored in liquid nitrogen freezers within the university's T.H. Chan School of Public Health. The samples are key to his award-winning research, which seeks a cure to multiple sclerosis and other neurodegenerative diseases. But for months, Ascherio has been unable to work with the samples because he lost $7 million in federal research funding, a casualty of Harvard's fight with the Trump administration. 'It's like we have been creating a state-of-the-art telescope to explore the universe, and now we don't have money to launch it,' said Ascherio. 'We built everything and now we are ready to use it to make a new discovery that could impact millions of people in the world and then, 'Poof. You're being cut off.'' Researchers laid off and science shelved The loss of an estimated $2.6 billion in federal funding at Harvard has meant that some of the world's most prominent researchers are laying off young researchers. They are shelving years or even decades of research, into everything from opioid addiction to cancer. And despite Harvard's lawsuits against the administration, and settlement talks between the warring parties, researchers are confronting the fact that some of their work may never resume. The funding cuts are part of a monthslong battle that the Trump administration has waged against some the country's top universities including Columbia, Brown and Northwestern. The administration has taken a particularly aggressive stance against Harvard, freezing funding after the country's oldest university rejected a series of government demands issued by a federal antisemitism task force. The government had demanded sweeping changes at Harvard related to campus protests, academics and admissions — meant to address government accusations that the university had become a hotbed of liberalism and tolerated anti-Jewish harassment. Research jeopardized, even if court case prevails Harvard responded by filing a federal lawsuit, accusing the Trump administration of waging a retaliation campaign against the university. In the lawsuit, it laid out reforms it had taken to address antisemitism but also vowed not to 'surrender its independence or relinquish its constitutional rights.' 'Make no mistake: Harvard rejects antisemitism and discrimination in all of its forms and is actively making structural reforms to eradicate antisemitism on campus," the university said in its legal complaint. 'But rather than engage with Harvard regarding those ongoing efforts, the Government announced a sweeping freeze of funding for medical, scientific, technological, and other research that has nothing at all to do with antisemitism.' The Trump administration denies the cuts were made in retaliation, saying the grants were under review even before the demands were sent in April. It argues the government has wide discretion to cancel federal contracts for policy reasons. The funding cuts have left Harvard's research community in a state of shock, feeling as if they are being unfairly targeted in a fight has nothing to do with them. Some have been forced to shutter labs or scramble to find non-government funding to replace lost money. In May, Harvard announced that it would put up at least $250 million of its own money to continue research efforts, but university President Alan Garber warned of 'difficult decisions and sacrifices' ahead. Ascherio said the university was able to pull together funding to pay his researchers' salaries until next June. But he's still been left without resources needed to fund critical research tasks, like lab work. Even a year's delay can put his research back five years, he said. Knowledge lost in funding freeze 'It's really devastating,' agreed Rita Hamad, the director of the Social Policies for Health Equity Research Center at Harvard, who had three multiyear grants totaling $10 million canceled by the Trump administration. The grants funded research into the impact of school segregation on heart health, how pandemic-era policies in over 250 counties affected mental health, and the role of neighborhood factors in dementia. At the School of Public Health, where Hamad is based, 190 grants have been terminated, affecting roughly 130 scientists. 'Just thinking about all the knowledge that's not going to be gained or that is going to be actively lost," Hamad said. She expects significant layoffs on her team if the funding freeze continues for a few more months. "It's all just a mixture of frustration and anger and sadness all the time, every day." John Quackenbush, a professor of computational biology and bioinformatics at the School of Public Health, has spent the past few months enduring cuts on multiple fronts. In April, a multimillion dollar grant was not renewed, jeopardizing a study into the role sex plays in disease. In May, he lost about $1.2 million in federal funding for in the coming year due to the Harvard freeze. Four departmental grants worth $24 million that funded training of doctoral students also were cancelled as part of the fight with the Trump administration, Quackenbush said. 'I'm in a position where I have to really think about, 'Can I revive this research?'' he said. 'Can I restart these programs even if Harvard and the Trump administration reached some kind of settlement? If they do reach a settlement, how quickly can the funding be turned back on? Can it be turned back on?' The researchers all agreed that the funding cuts have little or nothing to do with the university's fight against antisemitism. Some, however, argue changes at Harvard were long overdue and pressure from the Trump administration was necessary. Bertha Madras, a Harvard psychobiologist who lost funding to create a free, parent-focused training to prevent teen opioid overdose and drug use, said she's happy to see the culling of what she called 'politically motivated social science studies.' White House pressure a good thing? Madras said pressure from the White House has catalyzed much-needed reform at the university, where several programs of study have 'really gone off the wall in terms of being shaped by orthodoxy that is not representative of the country as a whole.' But Madras, who served on the President's Commission on Opioids during Trump's first term, said holding scientists' research funding hostage as a bargaining chip doesn't make sense. 'I don't know if reform would have happened without the president of the United States pointing the bony finger at Harvard," she said. 'But sacrificing science is problematic, and it's very worrisome because it is one of the major pillars of strength of the country.' Quackenbush and other Harvard researchers argue the cuts are part of a larger attack on science by the Trump administration that puts the country's reputation as the global research leader at risk. Support for students and post-doctoral fellows has been slashed, visas for foreign scholars threatened, and new guidelines and funding cuts at the NIH will make it much more difficult to get federal funding in the future, they said. It also will be difficult to replace federal funding with money from the private sector. 'We're all sort of moving toward this future in which this 80-year partnership between the government and the universities is going to be jeopardized,' Quackenbush said. 'We're going to face real challenges in continuing to lead the world in scientific excellence.'
Associated Press
3 days ago
- Health
- Associated Press
Harvard scientists say research could be set back years after funding freeze
CAMBRIDGE, Mass. (AP) — Harvard University professor Alberto Ascherio's research is literally frozen. Collected from millions of U.S. soldiers over two decades using millions of dollars from taxpayers, the epidemiology and nutrition scientist has blood samples stored in liquid nitrogen freezers within the university's T.H. Chan School of Public Health. The samples are key to his award-winning research, which seeks a cure to multiple sclerosis and other neurodegenerative diseases. But for months, Ascherio has been unable to work with the samples because he lost $7 million in federal research funding, a casualty of Harvard's fight with the Trump administration. 'It's like we have been creating a state-of-the-art telescope to explore the universe, and now we don't have money to launch it,' said Ascherio. 'We built everything and now we are ready to use it to make a new discovery that could impact millions of people in the world and then, 'Poof. You're being cut off.'' Researchers laid off and science shelved The loss of an estimated $2.6 billion in federal funding at Harvard has meant that some of the world's most prominent researchers are laying off young researchers. They are shelving years or even decades of research, into everything from opioid addiction to cancer. And despite Harvard's lawsuits against the administration, and settlement talks between the warring parties, researchers are confronting the fact that some of their work may never resume. The funding cuts are part of a monthslong battle that the Trump administration has waged against some the country's top universities including Columbia, Brown and Northwestern. The administration has taken a particularly aggressive stance against Harvard, freezing funding after the country's oldest university rejected a series of government demands issued by a federal antisemitism task force. The government had demanded sweeping changes at Harvard related to campus protests, academics and admissions — meant to address government accusations that the university had become a hotbed of liberalism and tolerated anti-Jewish harassment. Research jeopardized, even if court case prevails Harvard responded by filing a federal lawsuit, accusing the Trump administration of waging a retaliation campaign against the university. In the lawsuit, it laid out reforms it had taken to address antisemitism but also vowed not to 'surrender its independence or relinquish its constitutional rights.' 'Make no mistake: Harvard rejects antisemitism and discrimination in all of its forms and is actively making structural reforms to eradicate antisemitism on campus,' the university said in its legal complaint. 'But rather than engage with Harvard regarding those ongoing efforts, the Government announced a sweeping freeze of funding for medical, scientific, technological, and other research that has nothing at all to do with antisemitism.' The Trump administration denies the cuts were made in retaliation, saying the grants were under review even before the demands were sent in April. It argues the government has wide discretion to cancel federal contracts for policy reasons. The funding cuts have left Harvard's research community in a state of shock, feeling as if they are being unfairly targeted in a fight has nothing to do with them. Some have been forced to shutter labs or scramble to find non-government funding to replace lost money. In May, Harvard announced that it would put up at least $250 million of its own money to continue research efforts, but university President Alan Garber warned of 'difficult decisions and sacrifices' ahead. Ascherio said the university was able to pull together funding to pay his researchers' salaries until next June. But he's still been left without resources needed to fund critical research tasks, like lab work. Even a year's delay can put his research back five years, he said. Knowledge lost in funding freeze 'It's really devastating,' agreed Rita Hamad, the director of the Social Policies for Health Equity Research Center at Harvard, who had three multiyear grants totaling $10 million canceled by the Trump administration. The grants funded research into the impact of school segregation on heart health, how pandemic-era policies in over 250 counties affected mental health, and the role of neighborhood factors in dementia. At the School of Public Health, where Hamad is based, 190 grants have been terminated, affecting roughly 130 scientists. 'Just thinking about all the knowledge that's not going to be gained or that is going to be actively lost,' Hamad said. She expects significant layoffs on her team if the funding freeze continues for a few more months. 'It's all just a mixture of frustration and anger and sadness all the time, every day.' John Quackenbush, a professor of computational biology and bioinformatics at the School of Public Health, has spent the past few months enduring cuts on multiple fronts. In April, a multimillion dollar grant was not renewed, jeopardizing a study into the role sex plays in disease. In May, he lost about $1.2 million in federal funding for in the coming year due to the Harvard freeze. Four departmental grants worth $24 million that funded training of doctoral students also were cancelled as part of the fight with the Trump administration, Quackenbush said. 'I'm in a position where I have to really think about, 'Can I revive this research?'' he said. 'Can I restart these programs even if Harvard and the Trump administration reached some kind of settlement? If they do reach a settlement, how quickly can the funding be turned back on? Can it be turned back on?' The researchers all agreed that the funding cuts have little or nothing to do with the university's fight against antisemitism. Some, however, argue changes at Harvard were long overdue and pressure from the Trump administration was necessary. Bertha Madras, a Harvard psychobiologist who lost funding to create a free, parent-focused training to prevent teen opioid overdose and drug use, said she's happy to see the culling of what she called 'politically motivated social science studies.' White House pressure a good thing? Madras said pressure from the White House has catalyzed much-needed reform at the university, where several programs of study have 'really gone off the wall in terms of being shaped by orthodoxy that is not representative of the country as a whole.' But Madras, who served on the President's Commission on Opioids during Trump's first term, said holding scientists' research funding hostage as a bargaining chip doesn't make sense. 'I don't know if reform would have happened without the president of the United States pointing the bony finger at Harvard,' she said. 'But sacrificing science is problematic, and it's very worrisome because it is one of the major pillars of strength of the country.' Quackenbush and other Harvard researchers argue the cuts are part of a larger attack on science by the Trump administration that puts the country's reputation as the global research leader at risk. Support for students and post-doctoral fellows has been slashed, visas for foreign scholars threatened, and new guidelines and funding cuts at the NIH will make it much more difficult to get federal funding in the future, they said. It also will be difficult to replace federal funding with money from the private sector. 'We're all sort of moving toward this future in which this 80-year partnership between the government and the universities is going to be jeopardized,' Quackenbush said. 'We're going to face real challenges in continuing to lead the world in scientific excellence.'
Yahoo
4 days ago
- Entertainment
- Yahoo
Christina Applegate Hospitalized for Kidney Infection That Caused 'So Much Pain, I'm Screaming'
The actress shared that she's on IV antibiotics to treat an infection in her right kidney that since has spread to her leftNEED TO KNOW Christina Applegate shared that she's been hospitalized for an infection that's spread to both kidneys amid her ongoing struggle with multiple sclerosis Applegate said doctors intially wondered if she had a urinary tract infection and questioned her wiping technique Jokes aside, she admitted that she was a 'bag o'tears' and turned to the nurses for comfortChristina Applegate has been hospitalized for a kidney infection, which has since spread to both kidneys, causing her to be hospitalized with "so much pain" she said she's "screaming." The Married... With Children alum, 53, recorded the Tuesday, Aug. 5, episode of MeSsy, the podcast she co-hosts with Jamie-Lynn Sigler, from an L.A. hospital as she struggled with severe pain that made her feel like her appendix was bursting. While in Europe visiting family, Applegate said she began to feel unwell. On the flight back, however, she decided to go straight to the hospital, explaining she didn't want to wake up at 3 a.m. and need to run to the emergency room. 'I'm like, I wanna be admitted,' Applegate said, sharing her frustration with treatment during her multiple sclerosis struggle. She continued, 'I'm staying here because I want answers. I want every test that you can possibly think of or ones that you haven't even thought of, and I want them done.' The next day, she said, she woke up with an extreme pain on her right side. 'Of course, my brain's like, 'Oh, my appendix is bursting,' " Applegate recalled. The pain, she shared, was 'radiating' from the back to her front: 'So much pain. I'm screaming, and they ordered me an emergency CT at 2 in the morning,' she said, explaining that the scan showed she had a kidney infection — which has since spread to her left kidney as well. 'I'm just gonna be here,' she said, referring to her hospital stay and explaining, 'Because of this kidney infection, I have to have intravenous antibiotics right now. And that's where we're at.' The Dead to Me actress shared that doctors thought her condition could be a urinary tract infection, and questioned her wiping technique. 'Like, what am I back-wiping? Like, seriously, I'm 53,' she said, explaining that at a previous visit to the hospital, she'd been asked if she was wiping from front to back, as is recommended by doctors. Applegate said she has 'the cleanest vagina … I'm a clean girl down yonder.' Never miss a story — sign up for to stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories. While she was making jokes, Applegate admitted, "I'm holding in a bag o' tears right now." She added, "I sometimes fall into the nurse's arms like a freako, just like crying.' PEOPLE has reached out to Christina Applegate's reps for a statement and will update accordingly. Read the original article on People Solve the daily Crossword
Daily Mail
5 days ago
- Health
- Daily Mail
Researchers pinpoint key warning signs of MS that are routinely ignored... would YOU recognise them?
A new study has revealed fatigue, anxiety and pain are little known signs of multiple sclerosis (MS) that can strike 15 years before more well-known symptoms. Typical symptoms of the autoimmune condition include difficulties walking, vision problem, numbness and muscle cramps. The latest analysis looked at the health records of 12,000 people, tracking physician visits in the 25 years leading up to the onset of MS symptoms. It was the first study to examine healthcare usage this far back into a patient's clinical history. They found a steady increase in the number of visits to a GP as early as 15 years before neurological symptoms set in. This included an increase in visits to physicians for symptoms like fatigue, pain, dizziness, anxiety and depression. The visits to psychiatrists for mental health problems specifically increased 12 years before. But the researchers cautioned that not everyone who has these symptoms will go on to get the debilitating condition. They also found visits to neurologists and ophthalmologists—also known as eye doctors—for blurry vision or eye pain increased eight to nine years before. Then they saw an increase in visits to emergency and radiology departments three to five years before. And finally, they observed an increase in visits to specialist physicians like neurologists a year before. These patterns show signs 'something is happening beneath the surface' before it declares itself as MS, said Dr. Marta Ruiz-Algueró, a postdoctoral fellow at UBC, the study's first author. The earliest signs they observed 'can be easily mistaken for other conditions', warned Dr Helen Tremlett, professor of neurology at UBC's faculty. They believe their findings 'dramatically shift the timeline for when these early warning signs are thought to begin'. And they potentially open the door to opportunities for earlier detection and intervention, added Dr Tremlett. Previously other researchers had found symptoms that appear five years before, such as constipation, urinary tract infections, and sexual problems. MS is a life-changing, incurable condition affecting the brain and spinal cord that causes debilitating muscle spasms, among other symptoms. While MS does not directly kill, at advanced stages, it can cause weakness in the chest muscles, leading to difficulty breathing and swallowing—which can have life-threatening complications. Those in the late stage of the illness are also extremely vulnerable to potentially deadly infections. Some studies show that MS patients are up to 75 per cent more likely to die young than those without the disease. Most people find out they have MS in their thirties and forties, but the first signs can start years earlier. The latest study comes amid a concerning rise in cases, with around 150,000 people living with MS in the UK. This is up from around 130,000 in 2019, according to recent research by the MS Society. While experts don't know the reason cases are on the rise, possible factors are infections, a lack of vitamin D, smoking, solvents, obesity, and stress. It is important to spot the early signs of the condition, as while there is no cure for MS, treatments can slow the progression of the disease. The type of treatment you will need depends on the type of the disease patients have: relapsing remitting, secondary progressive, and primary progressive. Relapse and remitting MS involves flare-ups of symptoms where they get worse (relapse) and get better (remission). Over time it often develops into secondary progressive MS, when symptoms are there all the time, and get slowly worse. In the less common case of primary progressive MS, symptoms slowly getting worse over time without periods of them going away or getting better. Treatments may include several types of medication such as steroids, disease-modifying therapies, muscle relaxants, and those to treat pain and other symptoms. Other types of support include advice on fatigue, physiotherapy, mobility equipment, talking therapies, and cognitive rehabilitation.
